PAN: Pan Cancer Early Detection

OVERVIEW

Detecting Cancer Early

The aim of the PAN cancer study is to evaluate the potential of Breath Biopsy to detect various types of cancer by profiling Volatile Organic Compounds (VOCs) on breath. This serves as a first step in a research program evaluating the use of a breath test in early detection of cancer. 

The key parameter driving survival chances in patients with cancer is the stage at which the cancer is detected. Detection of cancer at its earliest stages, when it can be treated with curative intent, results in a dramatic improvement of survival rates whilst reducing treatment cost. Unfortunately, over half of cancers are detected when disease is more advanced, as early stages of cancer are typically asymptomatic. Internationally this paradigm has resulted in the implementation of national screening programs for breast, cervical, colorectal and lung cancer. The degree to which such programs have been implemented varies widely as they are typically associated with high costs, can be invasive and produce a high number of false positives results with consequent undesirable follow-up procedures and high resource utilisation. This has sparked ongoing debate about the utility of some of these programs and has prevented implementation of others. Therefore, there is a clear need for a low-cost, non-invasive and accurate test for early detection across a range of cancers.

The PAN study is a collaborative effort between Cambridge University Hospital NHS Foundation Trust, University of Cambridge, Cancer Research UK (CRUK) and Owlstone Medical.

CANCER TYPES

Cancer types in the PAN study

The PAN study will focus on seven cancer types and will initiate them over three staggered phases.

• Oesophageal
• Liver
• Gastric
• Pancreatic

• Renal
• Bladder
• Prostate