Maria Akiki at the 2020 Breath Biopsy Conference
Early Career presentation (20 min) - Detection of VOC biomarkers specific to chronic kidney disease by analysis of exhaled air from dialysis patients at advanced stages
The 2021 Breath Biopsy Conference is scheduled for 12th & 13th October. Click the button to express interest in the next Breath Biopsy Conference:
Talk Abstract:
Chronic kidney disease (CKD) is characterized by a progressive decrease in renal function during the different stages of development. At the beginning, this pathology remains “silent”, when in advanced stages, irreversible loss of kidney function leads to dialysis or kidney transplantation. Set up an early diagnosis for CKD is still needed in order to start treatments able to delay the dialysis. In France, this disease affects three million people and is very costly to society (billion euros). An emerging method is based on the detection of specific volatile organic compounds (VOC) in breath of CKD patients identified as biomarkers to improve the efficiency of the clinical approach of this disease. This work aims to establish a physicochemical VOC footprint typical of CKD by sampling exhaled air before and after dialysis of 43 volunteer CKD patients. Alveolar air is collected on pre-concentration tubes inserted into ReCIVA® Breath Sampler. Afterwards, the tubes were thermally desorbed and analyzed by chromatographic analysis GC-FID/MS. 356 VOC were detected. Among these species and by statistical methods (Wilcoxon), 24 VOC (alkane, alkene, alcohol, furan, aromatic and aldehyde) showed a significant decrease in their concentrations (µg/m3) at the end of the dialysis including new species compared to the bibliography. While 2 chlorinated VOC showed an increase in their concentrations at the end of dialysis. The results obtained are very encouraging and even if it still requires further studies it shows that breath analysis can become a useful method for the follow-up of patient’s with CKD.
Maria AKIKI* (presenting author), Jean-Luc WOJKIEWICZ*, Caroline DUC, François GLOWACKI+, Pascal KALUZNY°, Nadine LOCOGE
* IMT Lille Douai, Institut Mines-Télécom, University of Lille, Energy and Environment Centre, Lille, France
+ Service de Néphrologie, CHU Lille, F-59000, Lille, France
° TERA Environnement: 628 rue Charles de Gaulle 38920 CROLLES
Speaker Biography:
Maria Akiki received her Chemistry degree in 2016 from the Lebanese University, where she then completed a Master in Analytical Chemistry and a Master in Industrial Analysis. She is currently a PhD student at IMT Lille Douai in France, focusing on detection of VOC biomarkers in breath for chronic kidney disease.
The 2021 Breath Biopsy Conference is scheduled for 12th & 13th October. Click the button to express interest in the next Breath Biopsy Conference: