Pauline Poinot at the Breath Biopsy Conference 2021

The Breath Biopsy Conference 2022 is scheduled for 1^st-3^rd November. Click the button to express interest in the next Breath Biopsy Conference:

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Talk Abstract:

Volatolomics allows us to elucidate cell metabolic processes in real time. In particular, a volatile organic compound (VOC) excreted from our bodies may be specific for a certain disease, such that measuring this VOC may afford a simple, fast, accessible and safe diagnostic approach. Yet, finding the optimal endogenous volatile marker specific to a pathology is nontrivial because of interlaboratory disparities in sample preparation and analysis, as well as high interindividual variability. These limit the sensitivity and specificity of volatolomics and its applications in biological and clinical fields but have motivated the development of induced volatolomics. In this context, we have recently proposed a new strategy, that we’ve called “Induced Volatolomics”, that relies on the use of an off-on VOC-based probe which is converted into an exogenous volatile compound through a metabolic-specific enzymatic metabolism.

In this communication, an off-on VOC-based probe and its in vivo use to diagnose tumour-bearing animals will be described. Next, the interest of employing such a VOC based probe as a companion tool to predict, survey and improve the efficacy of novel chemotherapeutic agents will be shown. Finally, the scientific and clinical perspectives of off-on VOC-based probe will be presented.

Speaker Biography:
Pauline Poinot is a transdisciplinary researcher at IC2MP, Institute of Chemistry, University of Poitiers, France. After obtaining a master’s degree in Molecular Biochemistry, she graduated from a French Engineering School and then started a PhD on Flavor Chemistry and Sensory Analysis in Nantes. In 2010, she joined the French Alternative Energies and Atomic Energy Commission, Orsay, where she was trained to Proteomics with the investigation of protein biomarkers for Alzheimer’s disease in patient cerebrospinal fluid.

Pauline then joined the Institute of Chemistry of Poitiers where she has initiated a novel research group whose major objective is to develop Chemistry toolboxes for Biology. Thanks to her multidisciplinary background, she investigates Chemical and Biochemical strategies combining diverse “Omics” approaches with the aim to highlight and monitor relevant biomarkers involved either in the origin or the basic processes of any living system.

A recent illustration of her program is the development of a VOC-based probe that allows solid cancers diagnosis and prognosis in vivo in real time.

The Breath Biopsy Conference 2022 is scheduled for 1^st-3^rd November. Click the button to express interest in the next Breath Biopsy Conference:

Express Interest