Poster Audio: Breath Biopsy VOC Atlas: A List of Microbiome-Associated VOCs For Breath-Based Biomarker Discovery

Volatile organic compound (VOC) biomarkers in exhaled breath offer a promising solution to safe, non-invasive diagnostics in multiple disease settings. Some of these VOCs are linked to the gastrointestinal (GI) microbiome and could provide insight into disease development. Many breath-based studies have been performed in several disease conditions, but there are few validated breath biomarkers currently in clinical use.

The complex and unknown composition of the breath matrix makes identification and validation of on-breath VOC biomarkers challenging. Our Atlas study was designed to provide a comprehensive catalog of VOCs identified on exhaled human breath, the Breath Biopsy VOC Atlas®, to support the development of breath VOC biomarkers and diagnostics. The Atlas is a database containing VOCs linked to relevant metadata e.g. clinical data, sampling methods, and analysis methods detected by our OMNI® platform. Our OMNI platform can detect microbiome-associated VOCs such as short-chain fatty acids (SCFAs) and a wide range of VOCs including those linked to inflammation.

We recently presented this work at the American College of Gastroenterology (ACG) conference, and you can view our presentation below. If you are interested in finding out more, or meeting us at a conference, please get in touch.

We also presented this study at the 2024 Breath Biopsy Conference, which you can view here.