Poster Audio: Development of a new breath collection method for analyzing VOCs from intubated mouse models

Interstitial lung disease (ILD) is an umbrella term used for a large group of respiratory diseases that cause inflammation and scarring of the lungs. Idiopathic pulmonary fibrosis (IPF) is a form of ILD, where the lungs become scarred and fibrotic, meaning breathing becomes increasingly difficult. Early detection methods and more accurate biomarkers are needed to improve the treatment outcomes of IPF patients. To reduce the variability and challenges associated with biomarker development, utilizing mice in controlled laboratory settings is necessary for expediting the identification and validation of breath biomarkers for clinical use.

Therefore, we collaborated with Boehringer Ingelheim to develop a reliable system for studying mouse breath in the laboratory, that can be tailored for respiratory disease research. The platform we provide enhances on-breath VOC signals by significantly reducing background noise. This will improve foundational studies of breath and expedite the translation of breath analysis to the clinic. You can read our recently published paper on this methodology here.

We recently presented this work at the European Respiratory Society Congress (ERS) 2024 conference, and you can view our presentation below. If you are interested in finding out more, or meeting us at a conference, please get in touch.